Three new abietane diterpenoids from Podocarpus fleuryi |
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| Authors: | Lan-Chun Zhang Xing-De Wu Juan He Yan Li Rong-Ping Zhang Qin-Shi Zhao |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China |
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| Abstract: | Three new abietane diterpenoids, fleuryinols A–C (1–3), together with fourteen known compounds, were isolated from the twigs and leaves of Podocarpus fleuryi. Their structures were established by spectroscopic analysis, including 1D- and 2D-NMR spectroscopic techniques. Compounds 1–8 were tested cytotoxic activity against five human cancer cell lines, HL-60, SMMC-772, A-549, MCF-7, and SW480, of which fleuryinol B (2) and 19-hydroxyferruginol (4) exhibited moderate cytotoxic activity against some cell lines. |
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| Keywords: | Diterpenoids Fleuryinols A–C Cytotoxic activity |
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