Comparative effects of selenite and selenite on the glutathione-related enzymes activity in pig blood platelets |
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Authors: | Halina M. Zbikowska Barbara Wachowicz Tadeusz Krajewski |
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Affiliation: | (1) Department of General Biochemistry, University of Łódź, Łódź, Poland |
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Abstract: | The effects of inorganic selenium (Se) compounds (sodium selenite and selenate) on the activities of glutathione-related enzymes (glutathione peroxidase, glutathione-S-transferase [GST] and glutathione reductase [GR]) in pig blood platelets were investigated in vitro. GST activity in blood platelets treated with 10−4 M of selenite was reduced to 50%, whereas no decrease GST activity was observed after the treatment of platelets with the same dose of selenate. In platelets incubated with physiological doses (10−7, and 10−6 M) of Se compounds, the activity of glutathione peroxidase (GSH-Px) was enhanced (about 20%). GR activity after the exposure of platelets to tested Se compounds was unaffected. |
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Keywords: | Blood platelets sodium selenate and selenite glutathione peroxidase glutathione-S-transferase glutathione reductase |
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