Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium |
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Authors: | Liuxing Feng Xiao He Haiqing Xiao Zijie Li Fuliang Li Nianqing Liu Zhifang Chai Yuliang Zhao Zhiyong Zhang |
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Institution: | (1) Key Laboratory of Nuclear Analytical Techniques, and Institute of High Energy Physics, Chinese Academy of Sciences, 100049 Beijing, China;(2) Graduate School of the Chinese Academy of Sciences, 100049 Beijing, China |
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Abstract: | Lanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a
result, more and more lanthanides are entering the environment and eventually accumulating in the human body. Previous studies
indicate that the impact of lanthanides on brain function cannot be neglected. Although neurological studies of trace elements
are of paramount importance, up to now, little data are provided regarding the status of micronutritional elements in rats
after prenatal and long-term exposure to lanthanide. The aim of this study is to determine the ytterbium (Yb) and trace elements
distribution in brain and organic tissues of offspring rats after prenatal and long-term exposure to Yb. Wistar rats were
exposed to Yb through oral administration at 0,0.1, 2, and 40 mg Yb/kg concentrations from gestation day 0 through 5 mo of
age. Concentrations of Yb and other elements (Mg, Ca, Fe, Cu, Mn, and Zn) in the serum, liver, femur, and brain regions (cerebral
cortex, hippocampus, cerebellum, and the rest) of offspring rats at the age of 0 d, 25 d, and 5 mo were analyzed by inductively
coupled plasma-mass spectrometry. The accumulation of Yb in the brain, liver, and femur is observed; moreover, the levels
of Fe, Cu, Mn, Zn, Ca, and Mg in the brain and organic tissues of offspring rats are also altered after Yb exposure. This
disturbance of the homeostasis of trace elements might induce adverse effects on normal physiological functions of the brain
and other organs. |
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Keywords: | Ytterbium toxicology trace elements |
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