The co-induction of sister chromatid exchanges and virus synthesis in mammalian cells |
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| Authors: | About ScienceDirect |
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| Affiliation: | 1. Department of Medicine, Massachusetts General Hospital, Departments of Microbiology and Molecular Genetics and Medicine, Harvard Medical School, Boston, MA 02114, USA;2. Clinical Genetics Division, Children''s Hospital Medical Center, Boston, MA 02115, USA |
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| Abstract: | The induction of virus synthesis and sister chromatid exchange (SCE) formation was investigated in several mammalian cell lines. Ultraviolet light co-induced the production of virus and SCEs in Simian virus 40 (SV40) transformed hamster cells. Post-irradiation treatment with caffeine enhanced virus induction, though it caused a smaller, less consistent elevation of SCE formation. Co-induction of oncovirus synthesis and SCEs was also observed in three murine cell lines exposed to increasing concentrations of 5-bromodeoxyuridine. These and previous data demonstrate a correlation between the induction of virus synthesis and SCE formation in rodent cells exposed to several agents, although inter-agent variation in the correlation may reflect differences between the two processes. |
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