Cachectin/TNF as well as interleukin-1 induces prostacyclin synthesis in cultured vascular endothelial cells |
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| Authors: | M Kawakami S Ishibashi H Ogawa T Murase F Takaku S Shibata |
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| Affiliation: | 1. School of Geography, Environment & Earth Sciences, Victoria University of Wellington, Wellington, New Zealand;2. School of Earth Sciences, University of Melbourne, Parkville, Victoria, Australia |
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| Abstract: | Cachectin/tumor necrosis factor (cachectin/TNF) has been shown to be capable of stimulating prostacyclin (PGI2) production by vascular endothelial cells in vitro. The stimulation of PGI2 by cachectin/TNF is comparable to that observed with interleukin-1, the monokine previously suggested to be the principal mediator of this effect. The ability of cachectin/TNF to stimulate PGI2 production suggests that it may play a role in producing depressed blood pressure or shock. If so, it might be possible to prevent such adverse effects with the aid of anti-inflammatory agents. |
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