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Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1 |
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| Authors: | Lee K Jung W H Kang M Lee S H |
| Institution: | Life Science R&D, LG Chemical Ltd/Research Park, PO Box 61, Yu-Sung, Science Town, Taejon 305-380, South Korea |
| Abstract: | A series of noncovalent tripeptidic thrombin inhibitors incorporating a unidazolylethynyl moiety at P1 was investigated. A number of compounds of this series were highly potent and selective versus trypsin, and several compounds demonstrated good oral absorption in rats (F=58% for compound 19). |
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