UH series of monoclonal antibodies recognizing major histocompatibility complex class II antigen(s) of Japanese monkeys (Macaca fuscata) |
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Authors: | Y Murayama T Ishida K Hashiba A Noguchi O Takenaka |
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Institution: | Primate Research Institute, Kyoto University, Aichi, Japan. |
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Abstract: | Six mouse monoclonal antibodies were developed by immunization with a Japanese monkey cell line. These monoclonal antibodies, designated the UH series, reacted with large populations of peripheral B cells and monocytes, but not with T cells. The distribution of reactivities and the molecular weight of the membrane antigens recognized were similar to those of the HLA-DR monoclonal antibody; one inhibited the binding of HLA-DR. Human interferon-gamma induced increased expressions of all the UH antigen epitopes. |
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Keywords: | MHC class II Monoclonal antibodies Interferons Japanese monkey Macaca fuscata |
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