Effect of prolonged treatment with propionyl-L-carnitine on erucic acid-induced myocardial dysfunction in rats |
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Authors: | E. Pasini A. Cargnoni E. Condorelli A. Marzo R. Lisciani R. Ferrari |
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Affiliation: | (1) Cattedra di Cardiologia, Universita' degli Studi di Brescia, c/o Spedali Civili, P.le Spedali Civili, 1, 25123 Brescia, Italy |
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Abstract: | The aim of this study was to evaluate the ability of propionyl-L-carnitine to prevent cardiac damage induced by erucic acid. Rats were fed for 10 days with normal or 10% erucic acid—enriched diets with or without propionyl-L-carnitine intraperitoneally injected, (1 mM/kg daily, for 10 days). The erucic acid diet produced increases in triglycerides (from 5.6 to 12.4 mg/gww, P < 0.01), and free fatty acids (from 2.0 to 5.1 mg/gww, P < 0.01), but no changes in phospholipids. When the hearts were perfused aerobically with an isovolumic preparation there was no difference in mechanical activity. On the contrary, when pressure-volume curves were determined, the pressure developed by hearts from the erucic acid-treated rats were reduced.Independent of diet, propionyl-L-carnitine treatment always produced positive inotropy. This was concomitant with improved mitochondrial respiration (RCI 5.1 vs 9.3, P < 0.01), higher tissue ATP content (10.3 vs 18.4 mol/gdw P < 0.01) and reduction of triglycerides (12.4 vs 8.0 mg/gww, P < 0.01). These data suggest that propionyl-L-carnitine, when given chronically, is able to prevent erucic acid-induced cardiotoxicity, probably by reducing triglyceride accumulation and improving energy metabolism. |
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Keywords: | propionyl-L-carnitine erucic acid cardiomyopathy heart failure |
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