Antifungal activity of 5 new synthetic compounds vs. Trichophyton rubrum and Epidermophyton floccosum |
| |
Authors: | Romagnoli C Mares D Bruni A Andreotti E Manfrini M Vicentini CB |
| |
Institution: | (1) Department of Animal Biology, Section Botanical Garden, University of Modena e Reggio Emilia, Italy;(2) Department of Biology-Pharmaceutical Biology Lab., University of Ferrara, Italy;(3) Department of Pharmaceutical Sciences, Universityof Ferrara, Italy |
| |
Abstract: | The antifungal activity of five new synthetic compounds was evaluated on two dermatophytes: Epidermophyton floccosum and Trichophyton rubrum. The data showed that the imidazo-pyrazole and pyrazolo-thiazoles were not particularly effective, while the two pyrazole-thiocyanates
proved highly active on both fungi. The most active 5-amino-3-methyl-1-phenylpyrazolo-4-thiocyanate was chosen to perform
SEM and TEM morphological studies on both fungi. Both SEM and TEM observations revealed interesting alterations on the two
dermatophytes, particularly involving the endomembrane system.
This revised version was published online in June 2006 with corrections to the Cover Date. |
| |
Keywords: | Imidazo-pyrazoles pyrazolo-thiazoles pyrazoles antidermatophytic activity |
本文献已被 PubMed SpringerLink 等数据库收录! |