Bioactivity guided isolation of antifungal compounds from the liverwort Bazzania trilobata (L.) S.F. Gray |
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Authors: | Scher Jochen M Speakman John-Bryan Zapp Josef Becker Hans |
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Institution: | FR 8.7, Pharmakognosie und Analytische Phytochemie, Universit?t des Saarlandes, Postfach 151150, D-66041 Saarbrücken, Germany. |
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Abstract: | A dichloromethane and a methanol extract of the liverwort Bazzania trilobata showed antifungal activity against the phytopathogenic fungi Botrytis cinerea, Cladosporium cucumerinum, Phythophthora infestans, Pyricularia oryzae and Septoria tritici. Bioautography on thin-layer chromatograms was used to isolate six antifungal sesquiterpenes: 5- and 7-hydroxycalamenene, drimenol, drimenal, viridiflorol, gymnomitrol and three bisbibenzyls: 6 ',8'-dichloroisoplagiochin C, isoplagiochin D and 6'-chloroisoplagiochin D. Furthermore we report the isolation of gymnomitr-8(12)-en-4-one and the new coumarin 7,8-dihydroxycoumarin-7-O-beta-D-glucuronide. Their structures have been elucidated based on extensive NMR spectral evidence. |
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Keywords: | Bazzania trilobata Hepaticae Liverwort Antifungal Bioautography |
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