Salmonella typhimurium infection in high and low antibody responder mice: inverse correlation between antibody responsiveness and resistance to infection |
| |
Authors: | Osvaldo A Sant'Anna Solange Massa Denise Mouton Yolande Bouthillier Jean-Claude Mevel Olga M Ibanez Ruth Vassao Marcelo de Franco Raquel Bellinati Maria Siqueira Guido Biozzi |
| |
Institution: | Seçao de Imunologia, Instituto Biologico, Sao Paulo, Brazil;CNRS UPR A0305/Service d'Immunogénétique, Section de Biologie, Institut Curie, Paris, France;Seçao de Immunodiagnostico, Instituto Pasteur, Sao Paulo, Brazil;Seçao de Imunologia, Instituto Adolfo Lutz, Sao Paulo, Brazil |
| |
Abstract: | Abstract Susceptibility to Salmonella typhimurium infection was compared in H (high Ab responder) and L (low Ab responder) mice obtained by several selective breeding experiments (Selections I, II, III, IV and IV A) 10,19,22]. H mice were always much more susceptible to infection than their L mice counterparts within a continuous LD 50 variation range. In three of the selections (I, II and IV A) the low responsiveness character is known to result mainly from rapid Ag degradation in L mice macrophages. It was hypothesized that resistance to multiplication of intracellular pathogens could be related to an increased catabolic activity towards Ag. This was actually demonstrated, in F2 segregant hybrids of selection IV A, by the significant inverse correlation between capacity for Ab production and resistance to infection. |
| |
Keywords: | Salmonella infection Macrophage Polygenic control Antibody Innate resistance Mice |
|
|