Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals |
| |
| Authors: | Prattali Raphael R Barreiro Guilherme C Caliseo Caio T Fugiwara Felipe Y Ueno Mirian Prada Patrícia O Velloso Licio A Saad Mario J A Carvalheira José B C |
| |
| Affiliation: | Departamento de Clínica Médica, FCM, Universidade Estadual de Campinas (UNICAMP), 13081-970 Campinas, SP, Brazil. |
| |
| Abstract: | In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance. |
| |
| Keywords: | GH, growth hormone IR, insulin receptor IRS, insulin receptor substrate JNK, c-jun N terminal kinase PI 3-kinase, phosphatidylinositol 3-kinase WAT, white adipose tissue |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
