| 回肠Na+/胆汁酸转运体及其抑制剂的研究进展 |
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| 引用本文： | 封卫毅,侯家玉.回肠Na+/胆汁酸转运体及其抑制剂的研究进展[J].生理科学进展,2002,33(3):215-219. |
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| 作者姓名： | 封卫毅 侯家玉 |
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| 作者单位： | 北京中医药大学药理学教研室,北京,100102 |
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| 摘 要： | 回肠Na^ ／胆汁酸转运体是位于回肠末端、特异性吸收胆汁酸的一种Na^ 依赖性胆汁酸联合转运蛋白。该转运蛋白结构和功能的改变会引起胆汁酸叶收异常，进而影响到胆固醇和脂类的吸收。对该转运体及其抑制剂的研究，是寻找具有新作用机制降胆固醇的一条有效途径，目前正在受到人们的重视。
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| 关 键 词： | 回肠Na^＋／胆汁酸转运体 胆固醇 抑制剂 血脂调节药物 研究进展 |
Progress in the Study of Ileal Na+/ Bile Acid Transporter and Its Inhibitors |
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| FENG Wei Yi,HOU Jia Yu.Progress in the Study of Ileal Na+/ Bile Acid Transporter and Its Inhibitors[J].Progress in Physiological Sciences,2002,33(3):215-219. |
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| Authors: | FENG Wei Yi HOU Jia Yu |
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| Abstract: | Ileal Na +/ bile acid transporter is a Na + dependent bile acid cotransport protein , which is specifically responsible for bile acid uptake in the terminal ileum. Alteration in structure and function of the carrier may result in malabsorption of bile acid and affect the absorption of cholesterol and lipid. It is an effective way to find novel hypocholesterolemic drugs from the study of ileal Na +/ bile acid transporter and its inhibitors. |
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| Keywords: | Ileal Na +/ bile acid transporter Bile acid Cholesterol Inhibitor |
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