Role of casein kinase 1 in the glucose sensor-mediated signaling pathway in yeast |
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| Authors: | Satish Pasula Samujjwal Chakraborty Jae H Choi Jeong-Ho Kim |
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| Affiliation: | (1) The Mississippi Functional Genomics Network, Department of Biological Sciences, The University of Southern Mississippi, 118 College Dr, Hattiesburg, MS 39406, USA;(2) Department of Medicinal Chemistry and Pharmacognosy, Rockford Regional Program, University of Illinois at Chicago College of Pharmacy, 1601 Parkview Avenue, Rockford, IL 61107, USA;(3) Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, Oklahoma 73104, USA |
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| Abstract: | Background In yeast, glucose-dependent degradation of the Mth1 protein, a corepressor of the glucose transporter gene (HXT) repressor Rgt1, is a crucial event enabling expression of several HXT. This event occurs through a signaling pathway that involves the Rgt2 and Snf3 glucose sensors and yeast casein kinase 1 and 2 (Yck1/2). In this study, we examined whether the glucose sensors directly couple with Yck1/2 to convert glucose binding into an intracellular signal that leads to the degradation of Mth1. |
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