Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator |
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Authors: | Jee-Youn KimKyung-Ja So Sun LeeJae-Hoon Park |
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Affiliation: | Department of Pathology, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea |
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Abstract: | The Bcl-2 family proteins plays a central role in apoptosis. The pro- or anti-apoptotic activities of Bcl-2 family are dependent on the Bcl-2 homology (BH) regions. Bcl-rambo, a new pro-apoptotic member, is unusual in that its pro-apoptotic activity is independent of its BH domains. However, the mechanism underlying Bcl-rambo-induced apoptosis is largely unknown. Mitochondrial localization is indispensable for the pro-apoptotic function of Bcl-rambo. Bcl-rambo interacts physically with the adenine nucleotide translocator (ANT), suppresses the ADT/ATP-dependent translocation activity of ANT. Collectively, our data indicate Bcl-rambo is a pro-apoptotic member of the Bcl-2 family, induces the permeability transition via interaction with ANT.Structured summary of protein interactions:Bcl-Rambo and HSP60colocalize by fluorescence microscopy (View interaction)Bcl-rambobinds to ANT1 by pull down (View interaction) |
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Keywords: | ANT, adenine nucleotide translocator BA, bonkrekic acid BH, Bcl-2 homology CsA, cyclosporin A MMP, mitochondrial membrane potential MPT, mitochondrial permeability transition VDAC, voltage-dependent anion channel |
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