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Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading
Authors:Kurt WatsonRainelli Koumangoye  Pamela ThompsonAmos M Sakwe  Tina PatelSiddharth Pratap  Josiah Ochieng
Institution:a Departments of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, United States
b Departments of Microbiology, Meharry Medical College, Nashville, TN, United States
c Department of Cancer Biology, Vanderbilt University, Nashville, TN, United States
Abstract:Our goal in this study was to define the mechanisms by which fetuin-A mediates the adhesion of tumor cells. The data show that in the absence of fetuin-A, detached tumor cells secrete exosomes that contain most of the known exosomal associated proteins but lack the capacity to mediate cellular adhesion. In the presence of fetuin-A, the cells secrete exosomes, which contain, in addition to the other exosomal proteins, fetuin-A, plasminogen and histones. These exosomes mediate adhesion and cell spreading. Plasminogen is a participant in this novel adhesion mechanism. The data suggest that these exosomes play a role in tumor progression.
Keywords:SFM  serum free medium  BSA  bovine serum albumin  HBSS  Hank&rsquo  s balanced salt solution
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