Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents |
| |
Authors: | Sharma Vedula M Adi Seshu K V Chandra Sekhar V Madan Sachin Vishnu B Babu P Aravind Vamsee Krishna C Sreenu J Ravi Krishna V Venkateswarlu A Rajagopal Sriram Ajaykumar R Kumar T Sravan |
| |
Institution: | Discovery Chemistry, Dr. Reddy's Laboratories, Discovery Research, Miyapur, Hyderabad 500-049, India. sarmavm@drreddys.com |
| |
Abstract: | A new series of 4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose-response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400mg/kg doses were performed. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|