| 肿瘤治疗中的多细胞耐受性与三维细胞培养 |
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| 引用本文： | 贾茜 薛绍白 丰美福. 肿瘤治疗中的多细胞耐受性与三维细胞培养[J]. 细胞生物学杂志, 2004, 26(4): 394-398 |
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| 作者姓名： | 贾茜 薛绍白 丰美福 |
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| 作者单位： | [1]北京师范大学生命科学学院细胞生物学研究所细胞增殖与调控教育部重点实验室，北京100875 [2]中国科学院动物研究所生殖生物学中心，生物膜与膜生物工程国家重点实验室，北京100080 |
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| 摘 要： | 肿瘤治疗中的多细胞耐受性是由于体内肿瘤具有三维结构而产生的对药物、射线等作用的耐受性。近年来人们利用体外三维细胞培养技术研究多细胞耐受性，发现其机制主要为三维结构相关的耐受性和接触性耐受性，并发现一些逆转或减弱多细胞耐受性的方法，显示了其作为临床肿瘤单独治疗或联合治疗的应用前景。
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| 关 键 词： | 肿瘤 治疗 多细胞耐受性 三维细胞培养 药物 射线 |
| 修稿时间： | 2004-01-19 |
Multicellular Resistance in Cancer Therapy and Three-dimensional Cell Culture |
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| Qian Jia,Shao-Bai Xue,Mei-Fu Feng. Multicellular Resistance in Cancer Therapy and Three-dimensional Cell Culture[J]. Chinese Journal of Cell Biology, 2004, 26(4): 394-398 |
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| Authors: | Qian Jia Shao-Bai Xue Mei-Fu Feng |
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| Abstract: | Multicellular resistance (MCR) phenomenon in cancer treatment is due to there is the three-dimensional structure for tumor inside the body. In recent years, MCR phenomenon has been studied by using three-dimensional cell culture technology in vitro. It was found that the mechanism of MCR is mainly related to three-dimensional structure itself, i.e. intrinsic resistance and contact resistance. In addition, some methods were found to be able to reverse or decrease MCR, which might be used in cancer treatment by oneself or united with others in the future. |
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| Keywords: | multicellular resistance multicellular resistance mechanism multidrug resistance three-dimensional cell culture |
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