Burkholderia mallei and Burkholderia pseudomallei. Study of immuno- and pathogenesis of glanders and melioidosis. Heterologous vaccines] |
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| Authors: | I N Manzeniuk E A Galina V V Dorokhin I Ia Kalachev V N Borzenkov E A Svetoch |
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| Institution: | State Research Centre of Applied Microbiology, Obolensk, Moscow Region. |
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| Abstract: | Parameters of the infectious activity of B.mallei and B.pseudomallei for animals of various species were determined. Pathomorphological characteristics of the process of malleus and melioidosis were studied on golden hamsters, mice, guinea pigs, rats and monkeys. Tularemia, plague and salmonellosis vaccines were shown to have protective effects in experimental malleus and melioidosis. An insignificant cross immune response between the malleus and melioidosis pathogens was observed. |
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