Activities before and after stress of digestive enzymes in rats separated at different time from lactating females

The effect of separation of rat pups from lactating females at different time after birth (at the 18th, 21st, 30th, 36th or 43rd day) and stress exposed at the day of the experiment (at the 75th day of life) or twice (at the day of weaning and at the day of the experiment) on activities of membrane-bound (invertase, alkaline phosphatase, aminopeptidase M) and predominantly intracellular (glycyl-L-leucine dipeptidase) enzymes was studied in different parts of intestine of rats (males and females). A change of the enzyme activities has been shown for the first time in the animals separated from lactating females not only at early time, which has already been known, but also at later time, in comparison with their activities in the animals weaned at usual time, at the 30th day of life. The preliminary stress of rat pups at the day of separation from lactating females promotes in many cases a reduction of the response to the stress, to which the animal is exposed in the adult period of life. Deceased.