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Confidence bands for low-dose risk estimation with quantal response data |
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| Authors: | Al-Saidy Obaid M Piegorsch Walter W West R Webster Nitcheva Daniela K |
| Affiliation: | Department of Mathematics and Statistics, Sultan Qaboos University, Muscat, Oman. |
| Abstract: | We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD. |
| Keywords: | Benchmark analysis Benchmark dose Carcinogenic risk assessment Low-dose extrapolation Multistage model Quantal data Quantitative risk analysis Simultaneous confidence bounds Toxicology |
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