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Dual role of ryanodine-sensitive calcium stores in central neurons
Authors:O Garaschuk  A Konnerth
Institution:1. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine
2. I Physiologisches Institut, Universit?t des Saarlandes, Homburg, Germany
Abstract:The ryanodine-sensitive intracellular Ca2+ stores are known to play a major role in excitation-contraction coupling in muscles. Although these stores are also abundantly present in central neurons, their functional role in these cells remains unclear. Using fluorometric digital imaging of the intracellular Ca2+ concentration (Ca2+] i ) in rat hippocampal slices, we investigated the dynamic properties of the ryanodine-sensitive Ca2+ stores inCA1 hippocampal pyramidal cells. We found that at rest the ryanodine-sensitive Ca2+ stores are functioning predominantly as a “sink” for Ca ions responding to an increase in Ca2+] i with an increase in the amount of Ca ions accumulated inside the stores. If, however, Ca2+] i increases significantly, as happens during strong neuronal discharges, the ryanodine-sensitive Ca2+ stores respond with Ca2+ release, thus acting as an amplifier of the intracellular Ca2+ signal.
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