MicroRNAs in skeletal muscle biology and exercise adaptation |
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| Affiliation: | 1. Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan;2. Graduate Institute of Biomedical Informatics, Taipei Medical University, Taiwan;3. Division of Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan;4. Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Taiwan;5. Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, Taiwan;6. Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan;1. Department of Obstetrics and Gynecology, Bethune International Peace Hospital of PLA, Shijiazhuang, Hebei, China;2. Department of Urology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China;3. Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China;4. Orthopaedic Trauma Department 2, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China;1. Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Nowon-gil 75, Nowon-gu, Seoul 139-706, Republic of Korea;2. Laboratory of Biochemistry, School of Life Sciences and Biotechnology, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 136-701, Republic of Korea;3. Department of Pathology, Yonsei University Wonju College of Medicine, Ilsan-dong 162, Wonju, Kangwon-do 220-701, Republic of Korea |
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| Abstract: | MicroRNAs (miRNAs) have emerged as important players in the regulation of gene expression, being involved in most biological processes examined to date. The proposal that miRNAs are primarily involved in the stress response of the cell makes miRNAs ideally suited to mediate the response of skeletal muscle to changes in contractile activity. Although the field is still in its infancy, the studies presented in this review highlight the promise that miRNAs will have an important role in mediating the response and adaptation of skeletal muscle to various modes of exercise. The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed. |
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| Keywords: | MicroRNA MyomiR Skeletal muscle Exercise Free radicals |
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