Free radical paradoxes |
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| Affiliation: | 1. São Paulo State Public Servant Hospital, São Paulo, Brazil;2. Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA;3. Science Valley Research Institute, Santo André, São Paulo, Brazil;4. Albert Einstein Hospital, São Paulo, Brazil;5. Universidade Estadual Paulista (UNESP), Botucatu, Brazil;6. Santa Casa de Maceio, Maceio, Alagoas, Brazil;7. Hospital das Clínicas de Ribeirão Preto, São Paulo University Medical School (USP), Ribeirão Preto, São Paulo, Brazil;8. Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil;9. Beneficência Portuguesa de São Paulo, São Paulo, Brazil;10. Hospital das Clínicas de São Paulo, São Paulo University, São Paulo, Brazil;11. Vascular and Endovascular Surgery–Federal University of Bahia;12. Federal University of São Paulo, São Paulo, Brazil;13. Inova Heart and Vascular Institute, Falls Church, VA, USA;14. Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Center, Maywood, IL, USA |
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| Abstract: | Unlike bigger and more advanced animals, Caenorhabditis elegans does not generate NO, yet it was recently found that NO produced by chemical or biological sources exerts profound effects in that animal, leading to increased life span and thermotolerance. The biological source was Bacillus subtilis, a natural food for C. elegans. Yet once in the cell, NO might react with superoxide, leading to the production of the potentially toxic peroxynitrite. In this paper, a number of paradoxes that are involved in that situation are discussed. It is also argued that their solution might lead to a sizeable advancement of our knowledge of what constitutes oxidative stress and what role oxidative stress plays in the development of pathological processes and aging. |
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| Keywords: | Superoxide Superoxide dismutase Nitric oxide Peroxynitrite Aging Hydrogen peroxide |
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