Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids |
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| Affiliation: | 1. School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China;2. Center of Guangdong Food Green Processing and Nutrition Regulation Engineering Technology, South China University of Technology, Guangzhou, Guangdong Province, 510640, China;3. Department of Food Science, Cornell University, Ithaca, New York 14853, United States;4. Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan;1. Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA;2. Department of Medicine, Hematology/Oncology, University of Virginia, Charlottesville, VA 22908-0716, USA;3. University of Virginia Cancer Center, Charlottesville, VA 22908-0716, USA;4. Penn State Hershey Cancer Institute, Hershey, PA 17033, USA;5. Department of Pharmacology, University of Virginia, Charlottesville, VA 22908-0001, USA;1. Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile;2. Instituto Milenio, Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile;3. Laboratorios de Biomedicina, Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad Católica del Maule, Talca, Chile;4. Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States |
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| Abstract: | BackgroundConjugated linoleic acids (CLAs) are natural dairy food components that exhibit a unique body of potential health benefits in animals and man, including anti-cardiovascular disease and anti-cancer effects. Several studies have demonstrated that fatty acid synthase (FAS) levels (protein and mRNA) are over expressed in many carcinomas. Sterol regulatory element binding proteins (SREBPs) are transcription factors that regulate genes involved in lipid metabolism, including FAS.MethodsBreast cancer cell lines, MCF-7 and MDA-MB-231 were treated with CLAs to investigate the regulation of SREBP-1c and FAS expression.ResultsIn MDA-MB-231 cells, SREBP-1c and FAS were co-ordinately decreased by treatment with 25 μM CLA 9–11 and 10–12. In MCF-7 cells, the decrease in SREBP-1c and FAS expression was dependant on the concentration of CLA used.ConclusionsThe data suggest a differential effect of CLAs on SREBP-1c and FAS in estrogen receptor-positive (MCF-7) compared to estrogen receptor-negative (MDA-MB-231) breast cancer cells. |
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