Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors |
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| Affiliation: | 1. Department of Urology, Huadu District People’s Hospital, Southern Medical University,Guangzhou 510800, China;2. Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou 510515, China;3. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, China;1. Dipartimento di Biologia, Universita'' di Roma Tor Vergata, Italy;2. Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Fondation Recherche sur le Cancer et les Maladies du Sang, Hôpital Kirchberg Luxembourg, Luxembourg;3. Dipartimeno di Scienze Biomolecolari, Universita'' di Urbino Carlo Bo, Italy;4. Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea;5. Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Saudi Arabia |
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| Keywords: | AOM" },{" #name" :" keyword" ," $" :{" id" :" key0010" }," $$" :[{" #name" :" text" ," _" :" azoxymethane AR" },{" #name" :" keyword" ," $" :{" id" :" key0020" }," $$" :[{" #name" :" text" ," _" :" aldose reductase ARIs" },{" #name" :" keyword" ," $" :{" id" :" key0030" }," $$" :[{" #name" :" text" ," _" :" AR inhibitors CRC" },{" #name" :" keyword" ," $" :{" id" :" key0040" }," $$" :[{" #name" :" text" ," _" :" colorectal cancer DISC" },{" #name" :" keyword" ," $" :{" id" :" key0050" }," $$" :[{" #name" :" text" ," _" :" death-inducing signaling complex DR" },{" #name" :" keyword" ," $" :{" id" :" key0060" }," $$" :[{" #name" :" text" ," _" :" death receptor TNF" },{" #name" :" keyword" ," $" :{" id" :" key0070" }," $$" :[{" #name" :" text" ," _" :" tumor necrosis factor PARP" },{" #name" :" keyword" ," $" :{" id" :" key0080" }," $$" :[{" #name" :" text" ," _" :" poly(ADP-ribose) polymerase TRAIL" },{" #name" :" keyword" ," $" :{" id" :" key0090" }," $$" :[{" #name" :" text" ," _" :" tumor necrosis factor-related apoptosis-inducing ligand. Colon cancer TRAIL Aldose reductase Death receptors Apoptosis |
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