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Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells
Institution:1. Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, China;2. Department of Hepatobiliary and Pancreatic Surgery, Union Clinical Medical College, Fujian Medical University, Fuzhou 350108, China;3. Key Laboratory of Tumor Microbiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, China;1. Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan;2. Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan;3. Department of Medicine, Khyber Teaching Hospital Peshawar KPK, Pakistan;4. Division of Molecular Virology and Diagnostics Center of Excellence in Molecular Biology (CEMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan;5. Vice Chancellor Hazara University Mansehra, Pakistan;1. Liver Transplantation Center of the First Affiliated Hospital and Cancer Center, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China;2. Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0723, USA;1. Molecular Signaling Lab, Computational Systems Biology Research Group, BioMediTech and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, P.O.Box 553, 33101 Tampere, Finland;2. Institute for Systems Biology, 1441N 34th Street, Seattle, WA 98103-8904, USA;1. Division of Anesthesia and Intensive Care, Children''s Hospital V Buzzi, ASST FBF Sacco, Milan, Italy;2. Division of Cardiology, Children''s Hospital V Buzzi, ASST FBF Sacco, Milan, Italy;3. Department of Pediatrics, Children''s Hospital V Buzzi, ASST FBF Sacco, Milan, Italy
Abstract:
Keywords:Hepatitis B virus X protein  NAD(P)H:quinone oxidoreductase 1  Hepatocellular carcinoma  Epigenetic modification  Mitochondrial injury  Redox status  Free radicals
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