MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis |
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Authors: | Andrew Leask |
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Institution: | (1) Departments of Dentistry and Physiology and Pharmacology, University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1 |
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Abstract: | There is no therapy for chronic fibroproliferative diseases, in spite of the fact that current health statistics suggest that
these (which include cardiovascular disease, pulmonary fibrosis, diabetic nephropathy, liver cirrhosis and systemic sclerosis)
have been estimated to cause approximately 45% of the deaths in the developed world. Recently, many studies have shown that
mitogen activated protein kinases (MAPKs) are activated in response to fibrogenic agents and contribute to the formation and
function of the myofibroblast, the critical cell type responsible for excessive scarring. A recent report by Madala and colleagues
(Am J Respir Cell Mol Biol, 2011) has provided a proof-of-concept study showing that the specific MEK inhibitor ARRY-142886 (ARRY) can both suppress the progression
of fibrosis and reverse an animal model of lung fibrosis. Thus MEK inhibition could be a valuable method to treat lung fibrosis. |
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Keywords: | ctgf ccn2 mek/erk Iloprost Scleroderma Lung fibrosis |
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