Molecular evolution of Drosophila Sex-lethal and related sex determining genes |
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| Authors: | Charles Mullon Andrew Pomiankowski Max Reuter |
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| Affiliation: | (1) Department of Genetics, Environment and Evolution, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK;(2) Centre of Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, Physics Building, Gower Street, London, WC1E 6BT, UK |
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| Abstract: | Background Sex determining mechanisms are evolutionarily labile and related species often use different primary signals and gene regulatory networks. This is well illustrated by the sex determining cascade of Drosophila fruitflies, which have recruited Sex-lethal as the master switch and cellular memory of sexual identity, a role performed in other insects by the gene transformer. Here we investigate the evolutionary change in the coding sequences of sex determining genes associated with the recruitment of Sex-lethal. We analyze sequences of Sex-lethal itself, its Drosophila paralogue sister-or-Sex-lethal and downstream targets transformer and doublesex. |
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