Development of optical biosensor technologies for cardiac troponin recognition |
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| Authors: | Mojgan Abdolrahim Mohammad Rabiee Sanaz Naghavi Alhosseini Mohammadreza Tahriri Sara Yazdanpanah Lobat Tayebi |
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| Affiliation: | 1. Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran;2. Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI 53201, USA;5. Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA 94304, USA |
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| Abstract: | Acute myocardial infarction (AMI) is the leading cause of death among cardiovascular diseases. Among the numerous attempts to develop coronary marker concepts into clinical strategies, cardiac troponin is known as a specific marker for coronary events. The cardiac troponin concentration level in blood has been shown to rise rapidly for 4–10 days after onset of AMI, making it an attractive approach for a long diagnosis window for detection. The extremely low clinical sensing range of cardiac troponin levels consequently makes the methods of detection highly sensitive. In this review, by taking into consideration optical methods applied for cardiac troponin detection, we discuss the most commonly used methods of optical immunosensing and provide an overview of the various diagnostic cardiac troponin immunosensors that have been employed for determination of cardiac troponin over the last several years. |
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