Trimethine cyanine dyes as fluorescent probes for amyloid fibrils: The effect of N,N′-substituents |
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| Authors: | Marina V Kuperman Svitlana V Chernii Mykhaylo Yu Losytskyy Dmytro V Kryvorotenko Nadiya O Derevyanko Yurii L Slominskii Vladyslava B Kovalska Sergiy M Yarmoluk |
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| Institution: | 1. Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine (NASU), 03143 Kyiv, Ukraine;2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine (NASU), 02094 Kyiv, Ukraine |
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| Abstract: | The effect of various N,N′-substituents in the molecule of benzothiazole trimethine cyanine dye on its ability to sense the amyloid aggregates of protein was studied. The dyes are low fluorescent when free and in the presence of monomeric proteins, but their emission intensity sharply increases in complexes with aggregated insulin and lysozyme, with the fluorescence quantum yield reaching up to 0.42. |
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| Keywords: | Cyanine dyes Fluorescent probes Amyloid fibrils Protein aggregation Insulin Lysozyme |
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