Pyrimidine containing RSV fusion inhibitors |
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| Authors: | Nikitenko Antonia Raifeld Yuri Mitsner Boris Newman Howard |
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| Institution: | Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. nikitea@wyeth.com |
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| Abstract: | The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs. |
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