Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese |
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Authors: | Y-L Ko Yu-Shien Ko Shy-Meeng Wu Ming-Sheng Teng F-R Chen Tsu-Shiu Hsu Chen-Wen Chiang Ying-Shiung Lee |
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Institution: | (1) The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, No.199, Tung-Hua North Road, Taipei, Taiwan, Republic of China Tel.: +886-3-3281200, ext. 2313, 8171; Fax: +886-3-3973459, TW |
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Abstract: | To understand the effects of the interaction between genetic polymorphisms and obesity on the risk of hypertriglyceridemia
(HTG), two polymorphisms, an SstI polymorphism on the apolipoprotein CIII gene and a HindIII polymorphism on the lipoprotein lipase gene, were analyzed in 339 Chinese subjects with (82 cases in the HTG group) or
without HTG (257 cases in the control group). Our data revealed that the frequencies of obesity, the SstI minor allele (S2), and the HindIII major allele (H+) in the HTG group were significantly higher than in the control group. Subgroup analysis revealed that the association between
these two polymorphisms and HTG occurred predominantly in nonobese subjects and in subjects with the less hypertriglyceridemic
genotype of another polymorphism. Multivariate logistic regression analysis showed that all three risk factors (obesity, S2-containing chromosome, and H+ homozygosity) were associated with HTG, and an interaction was found between obesity and H+ homozygosity for the occurrence of HTG. The risk of HTG increased significantly with combinations of risk factors. Subjects
can be divided into low or high risk groups for HTG using such combinations. These results provide evidence of interaction
between obesity and the HindIII polymorphism of the lipoprotein lipase gene on the risk of HTG.
Received: 27 November 1996 / Accepted: 28 March 1997 |
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