DNA损伤检验点调控的分子机制

多种因素可以引起DNA损伤而最终导致基因产生错义突变、缺失或错误重组。为确保遗传准确性,细胞形成了复杂的细胞周期监督机制,即细胞周期检验点。其中DNA损伤检验点由许多检验点相关蛋白组成,可以识别损伤的DNA,经复杂的信号转导途径引发蛋白激酶的级联反应,减慢或阻滞细胞周期进程,从而为细胞修复损伤的DNA赢得时间。

The mechanism of DNA damage checkpoint control

DNA damage caused by many factors may lead to missense mutation,deletion or illegal recombination.To maintain genomic integrity,cells have evolved complex surveillance mechanisms termed cell cycle checkpoint.DNA damage checkpoint composed of various checkpoint-related proteins can sense DNA damage and execute cell cycle arrest through different signaling transduction pathway involving protein kinase cascades, thereby allowing time for cells to repair the damaged DNA.