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Stereoselective synthesis of 2-amino-1-hydroxy-3-phenylpropylphosphonic acid
Authors:Jan Zygmunt  Roman Gancarz  Barbara Lejczak  Piotr Wieczorek  Pawel Kafarski
Affiliation:aInstitute of Organic Chemistry, Biochemistry and Biotechnology, Technical University of Wroclaw, Wybrzeze Wyspiańskiego 27, 50-370 Wroclaw, Poland;bInstitute of Chemistry, University of Opole, Oleska 32, 45-052 Opole Poland
Abstract:A highly stereoselective synthesis of 2-amino-1-hydroxy-3-phenylpropylphosphonic acid was achieved by simple addition of diethyl phosphite to enantiomeric N-blocked phenylalaninals. These compouds exhibit significant herbicidal activity.
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