An Approximation to the Bayes Optimal Multi-Stage Design in the Colton Model for Clinical Trials |
| |
Authors: | P. Langenberg R. Srinivasan |
| |
Abstract: | A simple and operationally convenient approximation is proposed for the Bayes optimal multistage design within the Colton decision-theoretic model for the comparison of two medical treatments. The two- and three-stage designs are developed in full; the latter is found to be superior to several existing designs including some involving sequential adaptive sampling. |
| |
Keywords: | Colton model clinical trials multi-stage trial designs |
|