Circular dichroism study of modified nucleosides |
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Authors: | Andrzej Ga at,Aleksander Jankowski |
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Affiliation: | Andrzej Gałat,Aleksander Jankowski |
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Abstract: | CD study of four modified nucleosides, constituents of tRNA molecules, revealed that 2-thio-5-methyluridine and 5-methyluridine in aqueous solution, 0.1N HCl, and organic solvents essentially occur in an anti-conformation. 5-Methylcytidine also occurs in an anti-conformation similar to cytidine in aqueous solution and organic solvents, while 2-thiocytidine dihydrate appears to occur in an anti-conformation. It is stressed that the CD data of thionucleosides might be applied to the successfully conformational analysis of tRNA molecules. |
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