Two types of mammosomatotropes in mouse adenohypophysis |
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Authors: | Dr Fumihiko Sasaki Yoshie Iwama |
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Institution: | (1) Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture, Sakai, Japan;(2) Department of Anatomy, Aichi Medical University, Aichi, Japan;(3) Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture, Sakai, 591 Osaka, Japan |
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Abstract: | Summary Two types of mammosomatotropes (MS), the small-granule and vesicle-granule MS, were detected in mouse adenohypophysis by electron microscopy and immunohistochemistry. Both cell-types were immunoreactive to prolactin (PRL) and growth hormone (GH) antisera. The small-granule MS contained small, round, solid secretory granules about 100 nm in diameter, and were smaller than the classical GH and PRL cell-types. The vesicle-granule MS contained secretory granules like cored vesicles, and were larger than classical GH and PRL cells. Small-granule MS were immunoreactive to both PRL and GH antisera in the same region of the cell cytoplasm; the vesicle-granule MS, however, were immunoreactive to only PRL antiserum in most cytoplasmic areas, and a positive response to both PRL and GH antisera was confined to only certain small areas. |
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Keywords: | Mammosomatotropes Adenohypophysis Electron microscopy Immunohistochemistry Mouse (SMA) |
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