Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies |
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| Authors: | Bingbing Wei Zhuoqun Xu You Zhou Jun Ruan Huan Cheng Bo Xi Ming Zhu Ke Jin Deqi Zhou Qiang Hu Qiang Wang Zhirong Wang Zhiqiang Yan Feng Xuan Xing Huang Jian Zhang Hongyi Zhou |
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| Institution: | 1. Department of Urology, Affiliated Wuxi People’s Hospital, Nanjing Medical University, Wuxi, China.; 2. Faculty of Medicine, University of Helsinki, Finland.; 3. Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; 4. Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China.; The University of Texas M. D. Anderson Cancer Center, United States of America, |
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| Abstract: | BackgroundGlutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis.Methodology/Principal FindingsA comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR = 1.28, 95% CI: 1.11–1.48, P = 0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR = 1.35, 95% CI: 1.03–1.78, P = 0.03) but not among Caucasians (OR = 1.12, 95% CI: 0.96–1.31, P = 0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa.Conclusions/SignificanceThe present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians. |
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