Protective effect of exogenous coenzyme Q in rats subjected to partial hepatic ischemia and reperfusion. |
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| Authors: | M L Genova E Bonacorsi M D'Aurelio G Formiggini B Nardo S Cuccomarino P Turi M M Pich G Lenaz C Bovina |
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| Institution: | Department of Biochemistry G. Moruzzi, University of Bologna, Italy. |
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| Abstract: | In a surgical model of liver ischemia lipid peroxidation occurs, as shown by increase of lipid peroxidation end products, endogenous CoQ9 is oxidized and mitochondrial respiration is lowered; however, pre-treatment of the rats by i.p. injection of CoQ10 for 14 days normalizes the above parameters, presumably by way of the observed high extent of reduction of the incorporated quinone; moreover, liver homogenates of the CoQ10-treated rats are more resistant than those of non-treated rats to oxidative stress induced by an azido free radical initiator. This preliminary study suggests that CoQ10 pre-treatment can be of beneficial effect against oxidative damage during liver surgery transplantation. |
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