Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes. |
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| Authors: | G Radcliffe Y C Lin M Julius K B Marcu and J Stavnezer |
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| Institution: | Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655. |
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| Abstract: | We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha heavy-chain genes in immunoglobulin M-expressing cells of the I.29 mu B-cell lymphoma, a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. This germ line alpha RNA has a small open reading frame that does not include the C alpha domain, and this RNA appears to be present on polysomes in I.29 mu cells. |
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