Adaptive effects of hypoxic preconditioning in brain neurons |
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| Authors: | Samoĭlov M O Lazarevich E V Semenov D G Mokrushin A A Tiul'kova E I Romanovskiĭ D Iu Miliakova E A Dudkin K N |
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| Institution: | I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6. |
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| Abstract: | A preventive short-term hypoxia (preconditioning) increases neuronal resistance against subsequent strong hypoxic effects. Literature review and authors' own data on molecular-cellular mechanisms of the hypoxic preconditioning, are presented. Participation of intracellular signal transduction, genome, stress-proteins, and neuromodulating peptides in this process, is discussed. The role of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulating factors as the components of a "volume" signal transmission are analyzed in hypoxic precondition-associated induction of functional tolerance mechanisms against acute harmful effects in neurones of olfactory slices. |
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