Hunting for excitement: NMDA receptors in Huntington's disease |
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Authors: | Ellerby Lisa M |
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Institution: | Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. |
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Abstract: | Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excitotoxic death observed in Huntington's disease (HD) using a HD mouse model expressing full-length mutant huntingtin (htt). |
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