Effect of isoproterenol on the liberation of histamine from rat lung mast cells] |
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| Authors: | M R Vieytes M C Louzao L F de la Cruz L M Botana |
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| Affiliation: | Departamento de Fisiología, Facultad de Veterinaria, Lugo, Espa?a. |
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| Abstract: | Rat lung mast cells were stimulated with drugs with distinct mechanisms of action, namely concanavalin A, compound 48/80 ionophore A23187, in the presence of the beta adrenergic agonist (-)isoproterenol. Cells show a high response when they are stimulated with FNa-calcium. Isoproterenol does not inhibit histamine release induced by any stimuli, but enhances the response to concanavalin A and compound 48/80. Results point to the lack of beta activity on rat lung mast cells. |
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