Comparative effects of a highly specific protein kinase C inhibitor, calphostin C and calmodulin inhibitors on angiotensin-stimulated aldosterone secretion |
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Authors: | Arunabha Ganguly and Carolyn Waldron |
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Affiliation: | Department of Medicine, University of South Florida College of Medicine and James A. Haley Veterans Hospital, Tampa, Florida 33612, U.S.A. |
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Abstract: | We have examined the relative roles of the calcium-calmodulin system and protein kinase C in angiotensin-mediated aldosterone secretion. We used a highly specific protein kinase C inhibitor, calphostin C and two well-accepted calmodulin inhibitors, W-7 and calmidazolium. Although both types of inhibitors affected angiotensin-induced aldosterone secretion, as judged by the inhibitory doses of these compounds, angiotensin-evoked aldosterone secretion was more sensitive to calmodulin inhibition than protein kinase C inhibition. Manipulation of intracellular calcium by dantrolene and thapsigargin also modified aldosterone secretion significantly. |
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