Uptake of gamma-aminobutyric acid by human blood platelets: comparison with CNS uptake |
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Authors: | J W Hambley G A Johnston |
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Institution: | Department of Pharmacology University of Sydney Sydney NSW 2006 Australia |
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Abstract: | Human blood platelets show a sodium and temperature dependent uptake of gamma-aminobutyric acid (GABA) and other neuroactive amino acids. The most potent inhibitors tested of platelet GABA uptake were taurine and beta-alanine, while nipecotic acid and cis-3-aminocyclohexanecarboxylic acid were relatively weak inhibitors. These results suggest GABA is transported by a beta-amino acid uptake process in human platelets. Thus, platelet GABA uptake may more closely resemble glial rather than neuronal uptake. |
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