Schistosoma mansoni: effects of antimony on immature and adult worms. |
| |
Authors: | G C Coles L H Chappell |
| |
Institution: | Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire SK10 4TG, England, United Kingdom;Department of Zoology, University of Aberdeen, Aberdeen, Scotland, United Kingdom |
| |
Abstract: | Immature Schistosoma mansoni in mice are less susceptible to antimony therapy than adult worms. KSb tartrate inhibited phosphofructokinase (PFK) (EC 2.7.1.11) to a greater extent in extracts of 3-week-old worms than adults, and inhibited production of lactate in both immature and adult worms in vitro. In vivo, KSb tartrate was accumulated similarly by 3-week-old worms and by adults: measurements of hexosephosphate following drug treatment suggested similar inhibition of PFK in the two worm stages. If antimony acts by inhibition of PFK it is not clear why the young worms are more resistant to chemotherapy than adults. |
| |
Keywords: | Hexose phosphates Mode of action Phosphofructokinase EC 2 7 1 11 Potassium antimony tartrate Trematode |
本文献已被 ScienceDirect 等数据库收录! |
|