HIV-1 Vpu disarms natural killer cells |
| |
| Authors: | Richard Jonathan Cohen Éric A |
| |
| Affiliation: | Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal and Department of Microbiology and Immunology, Université de Montréal, Montreal, QC H2W 1R7, Canada. |
| |
| Abstract: | Natural killer (NK)-cell killing of virus-infected cells is regulated in part by the engagement of activation and coactivation receptors. In this issue of Cell Host & Microbe, Shah et?al. (2010) demonstrate that HIV-1 protects infected cells from NK-cell-mediated killing by hindering NK-cell degranulation through downmodulation of NTB-A coactivation receptor ligands by the Vpu accessory protein. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
