Branched antimicrobial peptides |
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| Authors: | A. Yu. Khrushchev I. A. Kashparov L. V. Klimenko Yu. V. Mitin |
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| Affiliation: | (1) Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia;(2) Faculty of Chemistry, Krasnoyarsk State University, pr. Svobodnyi 79, Krasnoyarsk, 660041, Russia |
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| Abstract: | Branched peptides E(RLAR)2, E[E(RLAR)2]2, and E(KLAR)2, E[E(KLAR)2]2 were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 μM for Escherichia coli cells, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes. |
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| Keywords: | antimicrobial peptides branched peptides dendrimers pentafluorophenyl esters |
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