Charting the progression of disability in parkinson disease: study protocol for a prospective longitudinal cohort study |
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| Authors: | Leland E Dibble James T Cavanaugh Gammon M Earhart Terry D Ellis Matthew P Ford Kenneth B Foreman |
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| Affiliation: | 1.Department of Physical Therapy,University of Utah,Salt Lake City,USA;2.Department of Physical Therapy,University of New England,USA;3.Program in Physical Therapy,Washington University in St. Louis-School of Medicine,USA;4.Department of Physical Therapy and Athletic Training,Boston University,USA;5.Department of Physical Therapy,School of Health Professions University of Alabama at Birmingham,USA |
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| Abstract: | Background People with Parkinson disease (PD), even in the presence of symptomatic relief from medical, surgical, and rehabilitative interventions, face a persistent worsening of disability. This disability is characterized by diminished quality of life, reduced functional mobility, declining performance in activities of daily living and worsening neurological impairments. While evidence has emerged supporting the clinically meaningful benefits of short-term exercise programs on these underlying factors, assertions regarding the effects of sustained programs of exercise and physical activity on the trajectory of disablement in PD are made in the absence of direct evidence. Indeed, the natural decline in quality of life and functional mobility in people diagnosed with PD is poorly understood. Moreover, outcome measures commonly used in clinical exercise trials typically do not capture the full spectrum of disability as defined by the World Health Organization (WHO). |
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